Catálogo de Investigaciones | 2011-2012

FACULTAD 138 Efficient synthesis of [PdL 2 Cl 2 ] complexes as precursors of improved chemotherapeutic drugs Cisplatin, cis -diamminedichloroplatinum(II), was the first inorganic compound to show antitumoral properties. Various unrelated Pt(II) compounds are active in a wide variety of cancer types and can overcome resistance mechanisms. The complex [Pt(NH 3 )(2-methylpyridine) Cl 2 ], ZD0473, is a well- known example of these new platinum drugs. In early stages of metal-based anticancer drug development, metals other than platinum were somewhat discarded based on reactivity profiles. Anyhow, an appropriate selection of ligands has produced palladium complexes with activities close to that exerted by cisplatin. Our research group is focused on the development of new palladium complexes of the type [Pd(N- Het) 2 Cl 2 ] as potential chemotherapeutic drugs and as precursors for additional functionalization. Approximately 20 complexes have been synthesized and obtained with a high purity in good yield. Their characterization includes elemental analysis as well as Infrared and 1 H-Nuclear Magnetic Resonance spectroscopy. Some of these complexes have been tested for biological activity with mixed results. These compounds are currently being used as precursors of novel complexes, which could result in improved chemotherapeutic drugs. dr. ramón l. hernández castillo palladium anticancer resistance