Catálogo de Investigaciones 2019-2020

114 FACULTAD Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations This study presents a large-scale screening method to find associations of cancer drugs with human genes. The analysis is focused on the current collection of Food and Drug Administration (FDA)-approved drugs (which includes about one hundred chemicals). The approach integrates global gene-expression transcriptomic profiles with drug- activity profiles of a set of 60 human cell lines obtained for a collection of chemical compounds (small bioactive molecules). Using a standardized expression for each gene versus standardized activity for each drug, Pearson and Spearman correlations were calculated for all possible pairwise gene- drug combinations. These correlations were used to build a global bipartite network that includes 1007 gene-drug significant associations. The data are integrated into an open web-tool called GEDA (Gene Expression and Drug Activity) which includes a relational view of cancer drugs and genes, disclosing the putative indirect interactions found for FDA- approved drugs as well as the known targets of these drugs. The results also provide insight into the complex action of pharmaceuticals, presenting an alternative view to address predicted pleiotropic effects of the drugs. Arroyo, M., Berral-González, A., Bueno-Fortes, S., Alonso- López, D. and De las Rivas, J., 2020. Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations. Biomolecules , 10(5), p.667. dra. mónica m. arroyo cabán departamento de química, pucpr bioinformatics and functional genomics group, cancer research center (cic-imbcc, csic/usal/ibsal), consejo superior de investigaciones científicas (csic) and university of salamanca (usal), 37007 salamanca, españa alberto berral gonzález santiago bueno fortes diego alonso lópez javier de las rivas bioinformatics and functional genomics group, cancer research center (cic-imbcc, csic/usal/ibsal), consejo superior de investigaciones científicas (csic) and university of salamanca (usal), 37007 salamanca, españa cancer cancer drug druck activity drug target gene expression

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